Treatment can be either an oral medication or a topical medication, or a combination of both. It is important to keep in mind that treatment for this condition. The medications do not clear the nail of the fungal involvement, but allows a new nail to grow without the fungal infection. Finally, this condition can reoccur. The best way to prevent re-occurrence of this condition is to treat any Athlete's foot that may be present, and prevent it from spreading back into the nails.